HCID 85126173, 화합물 → HCID 15223491, 화합물

HRID 1198610노트

반응식

HRID 1198610 반응식
[CH2:1]([N:8]1[CH2:12][CH:11]([C:13](=[N:15]O)[CH3:14])[CH2:10][C:9]1=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>N.[Ni]>[NH2:15][CH:13]([CH:11]1[CH2:12][N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9](=[O:17])[CH2:10]1)[CH3:14]

참가 물질

4

반응물 1

HCID 85126173HCID 85126173, 화합물

생성물 1

HCID 15223491HCID 15223491, 화합물수율 91.6%

시약·촉매·용매 2

HCID 935Nickel촉매2회HCID 222Ammonia용매

실험 절차

1-Benzyl-4-(1-hydroxyiminoethyl)-2-oxopyrrolidine (16.81 g, 0.072 mole), was hydrogenated in saturated methanolic ammonia (200 mL) at 50 psi and 25° with Raney nickel (5 g) for 23 hours. Additional Raney nickel (5 g) was added and hydrogenation continued for three hours. The reaction was Celite filtered and the solvent was removed under reduced pressure to give 4-(1-aminoethyl)-1-benzyl-2-oxopyrrolidine (14.4 g, 91%) as a brown oil which solidified on standing to a brown solid.

후처리

  1. filtrationfiltered
  2. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-f4031b5520b943d0a7d15cfddfdef667
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05281612

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