Tetrahydrofuran → 2-(4-Methylbutyloxy)acetaldehyde diethylacetal

HRID 1198719

반응식

HRID 1198719 반응식
C[C@H:2]([OH:6])[CH2:3][CH2:4][CH3:5].[H-].[Na+].[CH2:9]([O:11][CH:12]([O:15][CH2:16][CH3:17])[CH2:13]Br)[CH3:10].O1CCC[CH2:19]1>>[CH2:9]([O:11][CH:12]([O:15][CH2:16][CH3:17])[CH2:13][O:6][CH2:2][CH2:3][CH2:4][CH2:5][CH3:19])[CH3:10]

참가 물질

5

반응물 4

HCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 2724896(+)-2-Pentanol

생성물 1

HCID 199306252-(4-Methylbutyloxy)acetaldehyde diethylacetal

실험 절차

35 g of (S)-2-pentanol was dissolved in tetrahydrofuran, and 16 g of 60% sodium hydride was added thereto. After stirring for 30 minutes, 80 g of bromoacetaldehyde diethylacetal was added thereto, and the mixture was refluxed for 6 hours. After the reaction solution was concentrated and water and ether were added thereto, the mixture was shaken for mixing. The organic layer was collected and was dried with magnesium sulfate to remove the solvent off. Purification was carried out by column chromatography to obtain 2-(4-methylbutyloxy)acetaldehyde diethylacetal (54).

후처리

  1. temperaturethe mixture was refluxed for 6 hours
  2. concentrationAfter the reaction solution was concentrated
  3. additionwater and ether were added
  4. stirringthe mixture was shaken
  5. additionfor mixing
  6. customThe organic layer was collected
  7. dry with materialwas dried with magnesium sulfate
  8. customto remove the solvent off
  9. customPurification

출처 및 근거

ORD 기록
ord-d6ac1a34974f435dba56d16249472b73
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05281685

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