Hydrochloric Acid → 4-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol

반응식

[C:1]1([C:6]([NH:8][NH:9][C:10]([NH:12][CH3:13])=[S:11])=O)[S:5][CH:4]=[CH:3][CH:2]=1.C([O-])(O)=O.[Na+].Cl>>[CH3:13][N:12]1[C:6]([C:1]2[S:5][CH:4]=[CH:3][CH:2]=2)=[N:8][NH:9][C:10]1=[S:11]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 516892Sodium Bicarbonate

HCID 28198722-Thiophenecarboxylic acid, 2-[(methylamino)thioxomethyl]hydrazide

생성물 1

HCID 7219264-methyl-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol

실험 절차

1-(2-Thenoyl)-4-methylthiosemicarbazide (7.1 g, 3.3×10-2 mole) and 1 molar aqueous NaHCO3 (330 ml, 3.30×10-1 mole) were stirred and heated to reflux. After refluxing about 14 hours the reaction was filtered while hot and the filtrate was then cooled in an ice bath. Acidification by the dropwise addition of concentrated HCl (28 ml, 3.4×10-1 mole) gave a colorless precipitate which was collected by filtration, washed with a little cold H2O, and dried by suction. Crystallization from isopropanol gave colorless spears: 5.0 g (77%), mp 155°-157° C.