Methyl iodide → HCID 19866662, 화합물

HRID 1199448노트

반응식

HRID 1199448 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([C:15]1[NH:19][C:18]2[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=2[N:16]=1)=[O:14].CI.[C:26](=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:26][N:19]1[C:18]2[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=2[N:16]=[C:15]1[S:13]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:14]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 219575582-[2-(2-Pyridyl)-phenyl sulphinyl]-1H-benzimidazole

생성물 1

HCID 19866662HCID 19866662, 화합물수율 75.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-[2-(2-Pyridyl)-phenyl sulphinyl]-1H-benzimidazole (Example 13) (0.7 g) in dry dimethylformamide (50 ml), methyl iodide (0.34 g) and anhydrous potassium carbonate (1.1 g) were stirred at room temperature for 1.75 hours. The mixture was poured onto water, extracted into ethyl acetate, washed, dried and evaporated under reduced pressure to leave the title compound as a cream solid (0.55 g).

후처리

  1. additionThe mixture was poured onto water
  2. extractionextracted into ethyl acetate
  3. washwashed
  4. customdried
  5. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-07694a1e29374731b0c563de699b3429
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04900751

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