Hydrochloric Acid → 3-Isoquinolinecarboxylic acid,1,2,3,4-tetrahydro-6-hydroxy-,hydrochloride

HRID 1199669노트

반응식

HRID 1199669 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[CH2:5][C@@H:6]([C:8]([OH:10])=[O:9])[NH2:7].[CH2:14]=O.[ClH:16]>>[ClH:16].[OH:1][C:2]1[CH:3]=[C:4]2[C:11](=[CH:12][CH:13]=1)[CH2:14][NH:7][CH:6]([C:8]([OH:10])=[O:9])[CH2:5]2

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 6950578L-m-tyrosine

생성물 1

HCID 129261753-Isoquinolinecarboxylic acid,1,2,3,4-tetrahydro-6-hydroxy-,hydrochloride

실험 절차

To a mixture of 100.0 g of 3-hydroxyphenylalanine in 820 ml of 5% hydrochloric acid were added 78 ml of formaldehyde (37% in water). The reaction mixture was heated at 90°-95° C. (external bath temperature) for 45 minutes. The mixture was cooled and concentrated in vacuo. Five hundred milliliters of ethanol were added and the mixture was again concentrated in vacuo, affording 115 g of the title intermediate as a pale white solid, used without purification in the next step.

후처리

  1. temperatureThe reaction mixture was heated at 90°-95° C. (external bath temperature) for 45 minutes
  2. temperatureThe mixture was cooled
  3. concentrationconcentrated in vacuo
  4. additionFive hundred milliliters of ethanol were added
  5. concentrationthe mixture was again concentrated in vacuo

출처 및 근거

ORD 기록
ord-3e46a5c4658f44709ace3d572789c3f3
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04902695

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