Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(+/-)-trans-3-Ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione → (3S,4R)-4-(4-Fluorophenyl)-3-piperidinemethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (+/-)-trans-3-Ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione | HCID 11391819 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (3S,4R)-4-(4-Fluorophenyl)-3-piperidinemethanol | HCID 9855829 | 22% |
반응 단계
Compound E1 (±)-trans-3-ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione (2.0 g) was reduced with lithium aluminium hydride (0.58 g) in refluxing tetrahydrofuran (50 ml) for 4 hours. Work up as described in Example 5 gave the title compound as a solid (0.28 g, 22%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04902801 |
| 출처 데이터셋 | uspto-grants-1990_02 |
| ORD ID | ord-7d96f019b66a45868fd24994dd9a6a7a |
| 출처 메모 | uspto-grants-1990_02 |