(+/-)-trans-3-Ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione → (3S,4R)-4-(4-Fluorophenyl)-3-piperidinemethanol

HRID 1199802노트

반응식

HRID 1199802 반응식
C([O:3][C:4]([C@H:6]1[C@H:11]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[CH2:10][C:9](=O)[NH:8][C:7]1=O)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[F:18][C:15]1[CH:16]=[CH:17][C:12]([C@@H:11]2[CH2:10][CH2:9][NH:8][CH2:7][C@H:6]2[CH2:4][OH:3])=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 11391819(+/-)-trans-3-Ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione2회HCID 21226445Aluminium lithium hydride

생성물 1

HCID 9855829(3S,4R)-4-(4-Fluorophenyl)-3-piperidinemethanol수율 22%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Compound E1 (±)-trans-3-ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione (2.0 g) was reduced with lithium aluminium hydride (0.58 g) in refluxing tetrahydrofuran (50 ml) for 4 hours. Work up as described in Example 5 gave the title compound as a solid (0.28 g, 22%).

출처 및 근거

ORD 기록
ord-7d96f019b66a45868fd24994dd9a6a7a
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04902801

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