Dimethylformamide → Methyl 2-Chloro-5-iodonicotinate

HRID 1199807노트

반응식

HRID 1199807 반응식
CN(C)C=O.P(Cl)(Cl)([Cl:8])=O.[I:11][C:12]1[CH:13]=[C:14]([C:18]([O:20][CH3:21])=[O:19])[CH2:15][NH:16][CH:17]=1>C(Cl)Cl>[Cl:8][C:15]1[C:14]([C:18]([O:20][CH3:21])=[O:19])=[CH:13][C:12]([I:11])=[CH:17][N:16]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 20073492Methyl 5-iodo-1,2-dihydro-3-pyridinecarboxylate

생성물 1

HCID 2764559Methyl 2-Chloro-5-iodonicotinate수율 43%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution containing 0.12 ml of dry dimethylformamide and 0.14 ml of distilled phosphorus oxychloride in 20 ml of anhydrous methylene chloride are added 0.28 g of methyl 5-iodo-1,2-dihydro-3-pyridinecarboxylate in one portion. The mixture is stirred at room temperature under a nitrogen atmosphere for 28 hours. Workup as described in Procedure 1 yields 0.13 g (43%) of recrystallized methyl 2-chloro-5-iodo-3-pyridinecarboxylate.

출처 및 근거

ORD 기록
ord-da0fe0c031234f0899e7810d816d2956
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04902796

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