Stearyltrimethylammonium chloride → HCID 178442906, 화합물

HRID 1199832

반응식

HRID 1199832 반응식
[C:1]([C:4]1[CH:5]=[N:6][N:7]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)[C:8]=1[C:9]([NH2:11])=[O:10])([OH:3])=[O:2].[OH-].[Na+].[Cl-].[CH2:23]([N+:41]([CH3:44])([CH3:43])[CH3:42])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40]>CC(C)=O>[CH2:23]([N+:41]([CH3:44])([CH3:42])[CH3:43])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40].[C:1]([C:4]1[CH:5]=[N:6][N:7]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)[C:8]=1[C:9]([NH-:11])=[O:10])([OH:3])=[O:2]

참가 물질

5

반응물 3

HCID 8155Stearyltrimethylammonium chlorideHCID 14798Sodium HydroxideHCID 1638961H-Pyrazole-4-carboxylic acid, 5-(aminocarbonyl)-1-(3,5-dichlorophenyl)-

생성물 1

HCID 178442906HCID 178442906, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Five g of the compound of Example 2 was slurried in 100 ml of 50% aqueous acetone, 0.67 g of sodium hydroxide was added, and the mixture was warmed and stirred for 15 minutes. Then 10.6 g of octadecyl-trimethylammonium chloride, 50% solution, was added and the mixture was stirred overnight. It was then extracted with 100 ml of ethyl acetate, and the organic layer was washed with brine and dried with sodium sulfate and phase separation paper. The extract was then evaporated under vacuum to obtain 9.95 g of the desired product, m.p. 141°-144°. It was identified by elemental and nuclear magnetic resonance analysis.

후처리

  1. temperaturethe mixture was warmed
  2. stirringthe mixture was stirred overnight
  3. extractionIt was then extracted with 100 ml of ethyl acetate
  4. washthe organic layer was washed with brine
  5. dry with materialdried with sodium sulfate and phase separation paper
  6. customThe extract was then evaporated under vacuum

출처 및 근거

ORD 기록
ord-87b89bc8c523436fbd6346568f97acf5
출처 데이터셋
uspto-grants-1990_02
특허 번호
US04902808

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