Acetic Acid → 3-Hydroxy-2-phenyl-6-azabenzo[b]thiophene
반응식
[C:1]1([CH2:7][C:8]2[CH:9]=[N:10][CH:11]=[CH:12][C:13]=2[C:14](OC)=[S:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].C(O)(=[O:22])C>O1CCCC1.CN(C)C=O>[OH:22][C:8]1[C:13]2[CH:12]=[CH:11][N:10]=[CH:9][C:14]=2[S:15][C:7]=1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1참가 물질
6
반응 조건
- 온도
- 60 °C
실험 절차
A solution of 4.8 g (19 mmol) of methyl 3-phenylmethylthiopyridine-4-carboxylate in 10 mL of tetrahydrofuran was added to a slurry of 2.40 g (60 mmol) of 60% sodium hydride in 10 mL of N,N-dimethylformamide and the resulting mixture was stirred at 60° C. for 3 hours. The solution was poured onto ice water and acidified with glacial acetic acid. The filtrate was collected to afford 1.6 g (38%) of white solid.
후처리
- additionThe solution was poured onto ice water
- customThe filtrate was collected
출처 및 근거
- ORD 기록
- ord-366132b9327a4cdfad0571e4a08c35aa
- 출처 데이터셋
- uspto-grants-1990_02
- 특허 번호
- US04904672
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