Beta-Alanine → N-Acetyl-beta-alanine

HRID 12008

반응식

HRID 12008 반응식
[NH2:1][CH2:2][CH2:3][C:4]([OH:6])=[O:5].C(#N)C.[C:10](OC(=O)C)(=[O:12])[CH3:11]>C([O-])(O)=O.[Na+]>[C:10]([NH:1][CH2:2][CH2:3][C:4]([OH:6])=[O:5])(=[O:12])[CH3:11]

참가 물질

5

반응물 3

HCID 239Beta-AlanineHCID 6342AcetonitrileHCID 7918Acetic Anhydride2회

생성물 1

HCID 76406N-Acetyl-beta-alanine

시약·촉매·용매 1

HCID 516892Sodium Bicarbonate용매

실험 절차

To a solution of β-alanine (2.25 g, 25 mmol) in aq. NaHCO3 (15 mL) was added acetonitrile (15 mL) and acetic anhydride (2.55 g, 25 mmol). The reaction mixture was stirred at room temperature for 3 h. Acetic anhydride (2.55 g, 25 mmol) was added and after 2 h and pH was adjusted to 4-5 by addition of NaH2PO4.

출처 및 근거

ORD 기록
ord-8e758045aae44395ac6c2925d1fafcd3
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727713B2

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