Dichloromethane → Trans-4-(7-{[2-({4-[(diethoxyphosphoryl)methyl]-2-methoxyphenyl}amino)-5-(trifluoromethyl)pyrimidin-4-yl]amino}-2-methyl-1-oxo-2,3-dihydro-1H-isoindol-4-yl)cyclohexyl methanesulfonate

반응식

[CH3:48][CH2:49][N:50]([CH2:51][CH3:52])[CH2:53][CH3:54].[CH3:55][S:56]([Cl:57])(=[O:58])=[O:59].[CH3:63][N:64]([CH3:65])[c:66]1[cH:67][cH:68][n:69][cH:70][cH:71]1.[Cl:60][CH2:61][Cl:62].[OH:1][CH:2]1[CH2:3][CH2:4][CH:5]([c:8]2[cH:9][cH:10][c:11]([NH:19][c:20]3[n:21][c:22]([NH:30][c:31]4[c:32]([O:46][CH3:47])[cH:33][c:34]([CH2:35][P:36]([O:37][CH2:38][CH3:39])([O:40][CH2:41][CH3:42])=[O:43])[cH:44][cH:45]4)[n:23][cH:24][c:25]3[C:26]([F:27])([F:28])[F:29])[c:12]3[c:16]2[CH2:15][N:14]([CH3:17])[C:13]3=[O:18])[CH2:6][CH2:7]1>>[O:1]([CH:2]1[CH2:3][CH2:4][CH:5]([c:8]2[cH:9][cH:10][c:11]([NH:19][c:20]3[n:21][c:22]([NH:30][c:31]4[c:32]([O:46][CH3:47])[cH:33][c:34]([CH2:35][P:36]([O:37][CH2:38][CH3:39])([O:40][CH2:41][CH3:42])=[O:43])[cH:44][cH:45]4)[n:23][cH:24][c:25]3[C:26]([F:27])([F:28])[F:29])[c:12]3[c:16]2[CH2:15][N:14]([CH3:17])[C:13]3=[O:18])[CH2:6][CH2:7]1)[S:56]([CH3:55])(=[O:58])=[O:59]