Potassium Carbonate → 2-(4-t-Butylphenylthio)ethylamine

HRID 12015

반응식

HRID 12015 반응식
Cl.Cl[CH2:3][CH2:4][NH2:5].C([O-])([O-])=O.[K+].[K+].[C:12]([C:16]1[CH:21]=[CH:20][C:19]([SH:22])=[CH:18][CH:17]=1)([CH3:15])([CH3:14])[CH3:13]>C(Cl)(Cl)Cl>[C:12]([C:16]1[CH:17]=[CH:18][C:19]([S:22][CH2:3][CH2:4][NH2:5])=[CH:20][CH:21]=1)([CH3:15])([CH3:13])[CH3:14]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 754544-Tert-ButylbenzenethiolHCID 97937372-Chloroethylamine hydrochloride

생성물 1

HCID 136820922-(4-t-Butylphenylthio)ethylamine수율 74.1%

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
50 °C

실험 절차

To a stirring mixture of 4.36 g (38.0 mmol) of 2-chloroethylamine hydrochloride and 12.00 g (87.0 mmol) of K2CO3 in 30 mL of CHCl3 was added 4.82 g (29.0 mmol) of 4-t-butylbenzenethiol. The mixture was stirred at 50° C. in a sealed vial overnight. The mixture was washed three times with distilled water, dried with MgSO4 and filtered. Volatiles were removed in vacuo leaving 4.50 g (74%) of clear oil. 1H NMR (300 MHz, CDCl3): δ=7.32, m, 4H; 2.93, m, 4H; 1.42, broad singlet, 2H; 1.30, s, 9H.

후처리

  1. washThe mixture was washed three times with distilled water
  2. dry with materialdried with MgSO4
  3. filtrationfiltered
  4. customVolatiles were removed in vacuo

출처 및 근거

ORD 기록
ord-6acfba33d3264d7893baed6626e51411
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727926B2

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