Water → 2-Bromo-3-methylcyclohexanone

HRID 12055

반응식

HRID 12055 반응식
[Br:1]N1C(=O)CCC1=O.C([O-])(=O)C.[Na+].C[Si](C)(C)[O:16][C:17]1[CH2:22][CH2:21][CH2:20][CH:19]([CH3:23])[CH:18]=1.O>C1COCC1.O.C(OCC)(=O)C>[Br:1][CH:18]1[CH:19]([CH3:23])[CH2:20][CH2:21][CH2:22][C:17]1=[O:16]

참가 물질

7

반응물 4

HCID 962WaterHCID 67184N-bromobutanimideHCID 517045Sodium AcetateHCID 597981Trimethyl-(3-methyl-cyclohex-1-enyloxy)-silane

생성물 1

HCID 215419562-Bromo-3-methylcyclohexanone

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 21881883Oxolane--water (1/1)용매

실험 절차

A solution of N-bromosuccinimide (0.48 mmol) and sodium acetate (0.04 mmol) in THF/water (1:1, 5.2 ml) is cooled to 0° C. and trimethyl-(3-methyl-cyclohex-1-enyloxy)-silane (0.4 mmol, 80% pure) is added dropwise. The reaction mixture is heated to room temperature and stirring is continued overnight. After addition of water extraction is carried out with ethyl acetate. The title compound is obtained from the combined organic phases after drying over sodium sulphate and evaporating-off of the solvent in a vacuum (JOC 1997, 62, 19, 6692-6696).

출처 및 근거

ORD 기록
ord-9141ed1670cb49bcba55b96621509c0b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727979B2

연결된 노트

불러오는 중…