1-Bromohexane → HCID 178444669, 화합물

HRID 12062

반응식

HRID 12062 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[N:8]1[C:16]2[CH2:15][CH2:14][NH:13][CH2:12][C:11]=2[S:10][C:9]=1[NH:17][C:18]([NH2:20])=[NH:19].C(=O)([O-])[O-].[Cs+].[Cs+].[OH-].[Na+]>CN(C)C=O>[CH2:2]([N:13]1[CH2:14][CH2:15][C:16]2[N:8]=[C:9]([NH:17][C:18]([NH2:20])=[NH:19])[S:10][C:11]=2[CH2:12]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

6

반응물 4

HCID 81011-BromohexaneHCID 10796Cesium carbonateHCID 14798Sodium HydroxideHCID 178512601HCID 178512601, 화합물

생성물 1

HCID 178444669HCID 178444669, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1-bromohexane (0.11 mmol) is added to a suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine (0.1 mmol) and caesium carbonate (0.22 mmol) in dimethylformamide (0.3 ml) and the reaction mixture is stirred overnight at room temperature. After adding 2M caustic soda solution (1 ml) the mixture is extracted with ethyl acetate, the combined organic phases are dried over sodium sulphate and then concentrated by evaporation, the title compound being obtained in pure form.

후처리

  1. extractionis extracted with ethyl acetate
  2. dry with materialthe combined organic phases are dried over sodium sulphate
  3. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-6b14da6e27204bad9338c2861405d99d
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727979B2

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