Sulfuric Acid → HCID 22063473, 화합물

HRID 12096노트

반응식

HRID 12096 반응식
S(=O)(=O)(O)O.[CH2:6]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15]([CH3:18])(O)[CH3:16])=[CH:10][CH:9]=1)[CH3:7].[C:19](#[N:21])[CH3:20].[OH-:22].[Na+]>C(O)(=O)C>[CH2:6]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15]([NH:21][C:19](=[O:22])[CH3:20])([CH3:18])[CH3:16])=[CH:10][CH:9]=1)[CH3:7]

참가 물질

6

반응물 4

HCID 1118Sulfuric AcidHCID 6342AcetonitrileHCID 14798Sodium HydroxideHCID 22063451HCID 22063451, 화합물

생성물 1

HCID 22063473HCID 22063473, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

6.2 mL of concentrated sulfuric acid is added dropwise to 15.5 g (87 mmol) of 1-(4-ethylphenyl)-2-methylpropan-2-ol in 4.8 mL (91 mmol) acetonitrile and 15 mL glacial acetic acid within 15 minutes, during which time the temperature rises to 65° C. It is then stirred for one hour, diluted with ice water, and made alkaline with concentrated sodium hydroxide solution. After another 30 minutes' stirring, the solid precipitated is suction filtered and washed with water. The crude product is dissolved in ethyl acetate, dried with sodium sulfate, and evaporated down. The oil remaining is combined with petroleum ether, whereupon a solid is precipitated which is filtered off and dried. Yield: 16.3 g (85%); melting point 90° C.-92° C.

후처리

  1. customrises to 65° C
  2. stirringAfter another 30 minutes' stirring
  3. customthe solid precipitated
  4. filtrationfiltered
  5. washwashed with water
  6. dissolutionThe crude product is dissolved in ethyl acetate
  7. dry with materialdried with sodium sulfate
  8. customevaporated down
  9. customis precipitated which
  10. filtrationis filtered off
  11. customdried

출처 및 근거

ORD 기록
ord-c2a674e1238f4dc8b04cc0d29f019f60
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727984B2

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