Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 12268생성일: 2026년 10월 25일
1,3-Diethyl 2-oxopropanedioate → Diethyl 2-[2-(2-ethylaminopyrimidin-4-yl)-2-oxo-ethyl]-2-hydroxymalonate
https://huagongshe.com/reaction/12268
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,3-Diethyl 2-oxopropanedioate | HCID 69105 | — |
| 반응물 | 1-(2-(Ethylamino)pyrimidin-4-yl)ethanone | HCID 68452125 | — |
| 생성물 | Diethyl 2-[2-(2-ethylaminopyrimidin-4-yl)-2-oxo-ethyl]-2-hydroxymalonate | HCID 68452836 | — |
반응 단계
A mixture consisting of 1.9 g of 1-(2-ethylaminopyrimidin-4-yl)ethanone and 1.86 ml of diethyl ketomalonate is heated at 110° C. for 18 hours. The mixture is purified by column chromatography (silica gel, mobile phase:methylene chloride:methanol=98:2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07727989B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-0d9dbd0ceb884aa9952e31fab8bb9478 |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
