Dimethylformamide → 6-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2amino-4-chlorophenyl)amide

HRID 12271

반응식

HRID 12271 반응식
[CH2:1]([NH:3][C:4]1[N:9]=[C:8]([C:10]2[CH:11]=[C:12]([C:17]([OH:19])=O)[C:13](=[O:16])[NH:14][N:15]=2)[CH:7]=[CH:6][N:5]=1)[CH3:2].CN(C=O)C.C(N(CC)CC)C.[Cl:32][C:33]1[CH:38]=[CH:37][C:36]([NH2:39])=[C:35]([NH2:40])[CH:34]=1>O>[NH2:40][C:35]1[CH:34]=[C:33]([Cl:32])[CH:38]=[CH:37][C:36]=1[NH:39][C:17]([C:12]1[C:13](=[O:16])[NH:14][N:15]=[C:10]([C:8]2[CH:7]=[CH:6][N:5]=[C:4]([NH:3][CH2:1][CH3:2])[N:9]=2)[CH:11]=1)=[O:19]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 72634-Chloro-1,2-diaminobenzeneHCID 8471TriethylamineHCID 684533256-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid

생성물 1

HCID 866116046-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2amino-4-chlorophenyl)amide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 110 mg of 6-(2-ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid, 2 ml of DMF and 0.17 ml of triethylamine is mixed with 192 mg of Hatu and stirred at room temperature for 30 minutes. Then 66 mg of 4-chloro-phenylenediamine are added, and the mixture is stirred at room temperature overnight. 5 ml of water are added to the mixture, and the precipitate is briefly stirred and then filtered off with suction and dried.

후처리

  1. stirringthe mixture is stirred at room temperature overnight
  2. stirringthe precipitate is briefly stirred
  3. filtrationfiltered off with suction
  4. customdried

출처 및 근거

ORD 기록
ord-c6db62493a0541ae9904ac2a0c41fb10
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727989B2

연결된 노트

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