O-Methyltyramine → 8-Cyclohexyl-5-oxo-2-[2-(4-methoxy-phenyl)-ethylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

HRID 12361

반응식

HRID 12361 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH2:11])=[CH:5][CH:4]=1.[CH2:12]([O:14][C:15]([C:17]1[C:18](=[O:37])[C:19]2[CH:24]=[N:23][C:22](S(C)(=O)=O)=[N:21][C:20]=2[N:29]([CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)[CH:30]=1)=[O:16])[CH3:13]>>[CH2:12]([O:14][C:15]([C:17]1[C:18](=[O:37])[C:19]2[CH:24]=[N:23][C:22]([NH:11][CH2:10][CH2:9][C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)=[N:21][C:20]=2[N:29]([CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)[CH:30]=1)=[O:16])[CH3:13]

참가 물질

3

반응물 2

HCID 4657O-MethyltyramineHCID 252234828-Cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

생성물 1

HCID 685837848-Cyclohexyl-5-oxo-2-[2-(4-methoxy-phenyl)-ethylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

실험 절차

Using the procedure outlined in Example 28 Step F, the title compound was prepared from 2-(4-methoxy-phenyl)-ethylamine and 8-cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (from Example 35 (Step E), 35 mg, 0.09 mmol). 8-Cyclohexyl-5-oxo-2-[2-(4-methoxy-phenyl)-ethylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid (30 mg, 85%). Mass Spectrum (LCMS, ESI pos.) Calcd. For C25H30N4O4: 451.23 (M+H). Found: 451.2.

출처 및 근거

ORD 기록
ord-0912ed3cd556424e952f30aad94113c4
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728003B2

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