Potassium Carbonate → HCID 21933594, 화합물

HRID 1241239노트

반응식

HRID 1241239 반응식
C(=O)([O-])[O-].[K+].[K+].Br[CH2:8][CH2:9][C:10]([OH:12])=[O:11].[SH:13][C:14]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:15]=1[C:16]([O:18][CH3:19])=[O:17]>CC(C)=O>[OH:12][C:10]([CH2:9][CH2:8][S:13][C:14]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:15]=1[C:16]([O:18][CH3:19])=[O:17])=[O:11]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 115533-Bromopropionic acidHCID 1565712452948-12-6

생성물 1

HCID 21933594HCID 21933594, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

179.5 g (1.3 mol) of potassium carbonate and, a little at a time, 94.5 g (0.62 mol) of 3-bromopropionic acid were added to a solution of 125.4 g (0.62 mol) of methyl 2-mercapto-4-chlorobenzoate in 1.5 l of acetone, and the reaction mixture was stirred at room temperature for 12 hours. The solvent was distilled off, the residue was taken up in water and the mixture was extracted with diethyl ether. The aqueous phase was then made acidic using concentrated hydrochloric acid, and the resulting precipitate was filtered off with suction and dried. This gave 150 g (88%) of methyl 2-(2-hydroxycarbonyleth-1-yl)thio-4-chlorobenzoate.

후처리

  1. distillationThe solvent was distilled off
  2. extractionthe mixture was extracted with diethyl ether
  3. filtrationthe resulting precipitate was filtered off with suction
  4. customdried

출처 및 근거

ORD 기록
ord-284ab8b931e540ada41736c24d6676e3
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115545B1

반응 노트

불러오는 중…