Acetic Anhydride → N-(4-Chloro-3-nitrophenyl)acetamide

HRID 1242040

반응식

HRID 1242040 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(Cl)Cl>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:12](=[O:14])[CH3:13])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 124774-Chloro-3-nitroaniline

생성물 1

HCID 79672N-(4-Chloro-3-nitrophenyl)acetamide수율 96.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 4-chloro-3-nitroaniline (17.3 g, 100 mmol) in DCM (150 mL) was added dropwise acetic anhydride (14 mL, 150 mmol) at ambient temperature. The mixture was stirred at ambient temperature for 2.5 h. The solvent was removed in vacuo, and Et2O was added to the residue. The precipitate was collected by filtration, washed with Et2O, and dried in vacuo to give N-(4-chloro-3-nitrophenyl)acetamide (20.7 g, 96%), which was used without further purification.

후처리

  1. customThe solvent was removed in vacuo, and Et2O
  2. additionwas added to the residue
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with Et2O
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-3d521ee94b03429fa4532c87d2ff1686
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115640B2

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