Sodium borohydride → (6-(4-(Trifluoromethoxy)phenyl)pyridin-3-YL)methanol

HRID 1242305노트

반응식

HRID 1242305 반응식
[F:1][C:2]([F:19])([F:18])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:15]=[CH:14][C:13]([CH:16]=[O:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.[BH4-].[Na+]>CCO>[F:19][C:2]([F:1])([F:18])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 219356276-[4-(Trifluoromethoxy)phenyl]-3-pyridinecarbaldehyde

생성물 1

HCID 21935933(6-(4-(Trifluoromethoxy)phenyl)pyridin-3-YL)methanol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.00 g (7.48 mmol) of commercially available 6-(4-trifluoromethoxy-phenyl)-pyridine-3-carbaldehyde was dissolved in 37 ml of EtOH and treated at 0° C. with 0.283 g (7.48 mmol) of NaBH4. After 10 Min. the cooling bath was removed and stirring continued at ambient temperature. Pouring onto crashed ice, twofold extraction with AcOEt, washing with water, drying over sodium sulfate, and evaporation of the solvents afforded 2.08 g of pure title compound as off-white solid of mp. 57–58° C.

후처리

  1. customthe cooling bath was removed
  2. customcontinued at ambient temperature
  3. additionPouring
  4. extractionice, twofold extraction with AcOEt
  5. washwashing with water
  6. dry with materialdrying over sodium sulfate, and evaporation of the solvents

출처 및 근거

ORD 기록
ord-e7a0896eb32c48dabd40056b2f32ed17
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115611B2

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