Sodium Hydroxide → 2-(4-phenyl-1H-imidazol-1-yl)pyridine-3-carboxylic acid

HRID 12426노트

반응식

HRID 12426 반응식
[OH-].[Na+].[C:3]1([C:9]2[N:10]=[CH:11][N:12]([C:14]3[C:19]([C:20]([O:22]CC)=[O:21])=[CH:18][CH:17]=[CH:16][N:15]=3)[CH:13]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CO>[C:3]1([C:9]2[N:10]=[CH:11][N:12]([C:14]3[C:19]([C:20]([OH:22])=[O:21])=[CH:18][CH:17]=[CH:16][N:15]=3)[CH:13]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 66720067Ethyl 2-(4-phenyl-1H-imidazol-1-yl)pyridine-3-carboxylate

생성물 1

HCID 667200892-(4-phenyl-1H-imidazol-1-yl)pyridine-3-carboxylic acid수율 71.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

15 m of a 2N NaOH solution were added to a solution of 2.0 g of ethyl 2-(4-phenyl-1H-imidazol-1-yl)pyridine-3-carboxylate (6.82 mmol) in 30 ml of methanol, and the mixture was then stirred at room temperature for 2 hours. The reaction mixture was subsequently evaporated to dryness, mixed with 10 ml of H2O and neutralized by adding 2N HCl. Filtration with suction and drying the precipitate formed resulted in 1.3 g of the acid as brown amorphous solid.

후처리

  1. customThe reaction mixture was subsequently evaporated to dryness
  2. additionmixed with 10 ml of H2O
  3. additionby adding 2N HCl
  4. filtrationFiltration with suction
  5. customdrying the precipitate
  6. customformed

출처 및 근거

ORD 기록
ord-99393151c1744845bf4cf1d3a6c2e56e
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728012B2

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