4-Phenylbenzoyl chloride → HCID 58714508, 화합물

HRID 1242611

반응식

HRID 1242611 반응식
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[C:19]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:22](C(Cl)=O)=[CH:21][CH:20]=1.O[N:35]=[C:36]([NH2:43])[CH2:37][C:38]1[S:39][CH:40]=[CH:41][CH:42]=1>>[CH3:15][O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:16]2[O:18][N:43]=[C:36]([CH2:37][C:38]3[S:39][CH:40]=[CH:41][CH:42]=3)[N:35]=2)[N:8]([C:6]([C:31]2[CH:30]=[CH:29][C:28]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[CH:33][CH:32]=2)=[O:7])[CH2:12]1

참가 물질

4

반응물 3

HCID 841514-Phenylbenzoyl chlorideHCID 2737293N'-Hydroxy-2-(2-thienyl)ethanimidamideHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid2회

생성물 1

HCID 58714508HCID 58714508, 화합물

실험 절차

Following the general method as outlined in Example 59, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidine-carboxylic acid (Intermediate 2), [1,1′-biphenyl]-4-carbonyl chloride, and N′-hydroxy-2-(2-thienyl)ethanimidamide, the title compound was obtained in 85% purity by HPLC. MS(ESI+): m/z=459.2.

출처 및 근거

ORD 기록
ord-fb02a62e7ab94362b285a8913080bc0d
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115639B2

연결된 노트

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