Sodium Cyanide → 2-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)acetonitrile

HRID 1242681노트

반응식

HRID 1242681 반응식
[C-:1]#[N:2].[Na+].Br[CH2:5][C:6]1[C:10]2[CH:11]=[C:12]([Cl:15])[CH:13]=[CH:14][C:9]=2[S:8][C:7]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CS(C)=O>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]2[S:8][C:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[C:6]([CH2:5][C:1]#[N:2])[C:10]=2[CH:11]=1

참가 물질

4

반응물 2

HCID 8929Sodium CyanideHCID 219167743-Bromomethyl-5-chloro-2-phenylbenzo[b]thiophene

생성물 1

HCID 219172462-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)acetonitrile

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
60 °C

실험 절차

1.2 eq. of NaCN are suspended in 20 ml of dimethyl sulphoxide. The mixture is heated at 60° C. for 30 minutes and then 1 eq. of the compound obtained in Step C is added gradually. The reaction mixture is stirred for 1 hour at 60° C. and is then hydrolysed. Extraction with ethyl acetate is carried out and the organic phase is washed with water, dried over MgSO4 and evaporated under reduced pressure. The residue obtained is purified by chromatography on silica gel.

후처리

  1. extractionExtraction with ethyl acetate
  2. washthe organic phase is washed with water
  3. dry with materialdried over MgSO4
  4. customevaporated under reduced pressure
  5. customThe residue obtained
  6. customis purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-e0bee09081b744a9b761ebf4c446fd33
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115752B2

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