Hexylamine → [2-(Hexylamino)phenyl]methanol

반응식

Br[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[CH2:10]([NH2:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]>>[CH2:10]([NH:16][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

참가 물질

반응물 2

HCID 8102Hexylamine

HCID 728502-Bromobenzyl alcohol

생성물 1

HCID 15084054[2-(Hexylamino)phenyl]methanol수율 81%

실험 절차

Using the general procedure, 2-bromobenzyl alcohol (187 mg, 1.0 mmol) was coupled with n-hexylamine (198 μL, 1.5 mmol) at 90° C. for 22 h. Purification of the crude product by column chromatography on silica gel using hexane/ethyl acetate (6:1) as eluent afforded the desired product as a colorless liquid (168 mg, 81% yield). Rf=0.7 (hexane/ethyl acetate=2:1).

후처리

customPurification of the crude product by column chromatography on silica gel

출처 및 근거

ORD 기록: ord-2441703ddc534db5b131aa484afaffb0
출처 데이터셋: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07115784B2

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