Dimethylformamide → Methyl 8-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

HRID 1243144노트

반응식

HRID 1243144 반응식
[CH3:1]N(C=O)C.[CH3:6][O:7][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:17]=1[CH2:16][CH:15]([C:18]([OH:20])=[O:19])[CH2:14][CH2:13]2.CI.C([O-])([O-])=O.[K+].[K+]>C(OCC)(=O)C>[CH3:1][O:19][C:18]([CH:15]1[CH2:14][CH2:13][C:12]2[C:17](=[C:8]([O:7][CH3:6])[CH:9]=[CH:10][CH:11]=2)[CH2:16]1)=[O:20]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 36247098-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic Acid

생성물 1

HCID 13058286Methyl 8-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a DMF solution (30 mL) of 8-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (5.0 g, 24 mmol) was added MeI (7.1 g, 50 mmol) and K2CO3 (6.9 g, 50 mmol). The mixture was allowed to stir overnight and ethyl acetate (200 mL) was added. The resulting solution was washed with water (3×50 mL) and brine (50 mL) to provide 8-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid methyl ester (6.6 g).

후처리

  1. washThe resulting solution was washed with water (3×50 mL) and brine (50 mL)

출처 및 근거

ORD 기록
ord-3ff1f3a69cb44de592296d9aced13302
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115767B2

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