Hydrochloric Acid → 4-Fluoro-3-methoxyaniline hydrochloride

HRID 1243219노트

반응식

HRID 1243219 반응식
C(OC([NH:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[C:11]([O:16][CH3:17])[CH:10]=1)=O)(C)(C)C.[ClH:18]>O1CCOCC1>[ClH:18].[F:15][C:12]1[CH:13]=[CH:14][C:9]([NH2:8])=[CH:10][C:11]=1[O:16][CH3:17]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 21062601(Tert-butoxy)-n-(4-fluoro-3-methoxyphenyl)carboxamide

생성물 1

HCID 219392834-Fluoro-3-methoxyaniline hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

(tert-Butoxy)-N-(4-fluoro-3-methoxyphenyl)carboxamide (0.98 g, 4.06 mmol) (from Example 34c supra) was treated with 4 N hydrochloric acid in dioxane (20 mL) (Aldrich) overnight at room temperature. The resulting precipitate was collected by filtration and washed with dry ether to give 4-fluoro-3-methoxyphenylamine hydrochloric acid salt as a white, crystalline, solid. (Yield 512 mg, 71%).

후처리

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with dry ether

출처 및 근거

ORD 기록
ord-8c860e4d6b594c88a30618a5e7f3bf63
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07115740B2

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