4-Bromopyridine → 1-pyridin-4-yl-1,4-diazepane

HRID 1243329노트

반응식

HRID 1243329 반응식
Br[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[NH:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[OH-].[Na+]>O>[N:5]1[CH:6]=[CH:7][C:2]([N:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:3][CH:4]=1

참가 물질

5

반응물 3

HCID 142684-BromopyridineHCID 14798Sodium HydroxideHCID 68163Hexahydro-1,4-diazepine

생성물 1

HCID 27605081-pyridin-4-yl-1,4-diazepane수율 40.1%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 2 g of 4-bromopyridine and 10 g of homopiperazine is heated at 100° C. for 4 hours. 100 ml of water are added to the reaction mixture and the resulting mixture is basified to pH 10 by addition of 10% NaOH solution and extracted three times with 100 ml of chloroform, the organic phase is dried over Na2SO4 and the solvent is evaporated off under vacuum. 0.9 g of the expected product is obtained.

후처리

  1. extractionextracted three times with 100 ml of chloroform
  2. dry with materialthe organic phase is dried over Na2SO4
  3. customthe solvent is evaporated off under vacuum

출처 및 근거

ORD 기록
ord-e45bd25b6bab40cb95ed25343601ba20
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07119086B2

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