Hydrazine hydrate (1:1) → 1-(Pyridin-2-yl)piperidine-4-carbohydrazide

HRID 1243554노트

반응식

HRID 1243554 반응식
O.[NH2:2][NH2:3].C([O:6][C:7]([CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:11][CH2:10]1)=O)C>CC(O)C>[N:12]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:13][CH2:14][CH:9]([C:7]([NH:2][NH2:3])=[O:6])[CH2:10][CH2:11]1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 38156184-Piperidinecarboxylic acid, 1-(2-pyridinyl)-, ethyl ester

생성물 1

HCID 235440481-(Pyridin-2-yl)piperidine-4-carbohydrazide

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

Hydrazine hydrate (61.4 ml, 1.265 mol) was charged to a propan-2-ol solution of 3,4,5,6-Tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid ethyl ester (0.253 mol, 5 ml/g)(see reference Farmaco, 1993, 48(10), 1439), before heating under reflux for 18 hours. The mixture was cooled to room temperature and then to 10° C. and the product, a white solid, was collected by filtration (44.5 g).

후처리

  1. temperaturebefore heating
  2. temperatureunder reflux for 18 hours
  3. filtrationto 10° C. and the product, a white solid, was collected by filtration (44.5 g)

출처 및 근거

ORD 기록
ord-47f7af1a073c43c8a84e06dc7e145484
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07119088B2

반응 노트

불러오는 중…