Sodium Azide → (R)-4-azido-1,1,1-trifluoro-2-butanol

HRID 1243613노트

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HRID 1243613 반응식
[F:1][C:2]([F:9])([F:8])[C@H:3]([OH:7])[CH2:4][CH2:5]I.[N-:10]=[N+:11]=[N-:12].[Na+]>CS(C)=O.O>[N:10]([CH2:5][CH2:4][C@@H:3]([OH:7])[C:2]([F:9])([F:8])[F:1])=[N+:11]=[N-:12]

참가 물질

5

반응물 2

HCID 33557Sodium AzideHCID 22874097(R)-1,1,1-trifluoro-4-iodo-2-butanol

생성물 1

HCID 21064884(R)-4-azido-1,1,1-trifluoro-2-butanol수율 100.1%

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

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온도
50 °C

실험 절차

A solution of (R)-1,1,1-trifluoro-4-iodo-2-butanol (3.30 g, 13.0 mmol) in DMSO (22 mL) was treated with sodium azide (0.930 g, 14.3 mmol) at ambient temperature, followed by heating at 50° C. for 20 h. The mixture was diluted with cold water (250 mL) and extracted with diethyl ether. The combined organic extracts were washed (brine), dried, and evaporated without heat to give the product as a pale yellow oil (2.20 g, 100%).

후처리

  1. extractionextracted with diethyl ether
  2. washThe combined organic extracts were washed (brine)
  3. customdried
  4. customevaporated
  5. temperaturewithout heat

출처 및 근거

ORD 기록
ord-d2c398c1965c4c7d87929722f998f964
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07119109B2

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