홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Cyclopropylamine → (N-cyclopropyl)-6,6-diphenyl-6,7-dihydro-1H-indazole-3-carboxamide

HRID 1243823
노트
인쇄 미리보기

반응식

HRID 1243823 반응식
[C:1]1([C:7]2([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:15][C:14]3[NH:13][N:12]=[C:11]([C:16]([OH:18])=O)[C:10]=3[CH:9]=[CH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:25]1([NH2:28])[CH2:27][CH2:26]1.Cl.C(N=C=NCCCN(C)C)C.OC1C2N=NNC=2C=CC=1>ClCCl>[CH:25]1([NH:28][C:16]([C:11]2[C:10]3[CH:9]=[CH:8][C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)([C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:15][C:14]=3[NH:13][N:12]=2)=[O:18])[CH2:27][CH2:26]1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 69828CyclopropylamineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 219286736,6-diphenyl-6,7-dihydro-1H-indazole-3-carboxylic acidHCID 178418300HCID 178418300, 화합물

생성물 1

HCID 21929970(N-cyclopropyl)-6,6-diphenyl-6,7-dihydro-1H-indazole-3-carboxamide

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

반응 조건

온도
20 °C

실험 절차

Starting with a mixture of 1.23 g of 6,6-diphenyl-6,7-dihydro-1H-indazole-3-carboxylic acid, 0.26 cm3 of cyclopropylamine, 0.86 g of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 60 mg of hydroxybenzotriazole in solution in 30 cm3 of dichloromethane, and after stirring for 18 hours at a temperature in the region of 20° C., washing with twice 30 cm3 of distilled water and purifying the crude product obtained by flash chromatography on silica gel (30–70 μm), eluting with a cyclohexane/ethyl acetate (60/40) mixture, 0.58 g of (N-cyclopropyl)-6,6-diphenyl-6,7-dihydro-1H-indazole-3-carboxamide is obtained in the form of a yellow solid, the characteristics of which are as follows:

후처리

  1. washwashing with twice 30 cm3 of distilled water
  2. custompurifying the crude product
  3. customobtained by flash chromatography on silica gel (30–70 μm)
  4. washeluting with a cyclohexane/ethyl acetate (60/40) mixture

출처 및 근거

ORD 기록
ord-677c95aaa1d742788d93011560fa819f
출처 데이터셋
uspto-grants-2006_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07119115B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트