Diiodomethane → HCID 21928792, 화합물
반응식
N(OCCC(C)C)=O.[C:9]1([C:15]2([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH2:23][C:22]3[N:21]([S:24]([C:27]4[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][CH:28]=4)(=[O:26])=[O:25])[N:20]=[C:19](N)[C:18]=3[CH:17]=[CH:16]2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[I:41]CI>>[I:41][C:19]1[C:18]2[CH:17]=[CH:16][C:15]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=3)([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH2:23][C:22]=2[N:21]([S:24]([C:27]2[CH:28]=[CH:29][C:30]([CH3:33])=[CH:31][CH:32]=2)(=[O:26])=[O:25])[N:20]=1참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
1.21 cm3 of isoamyl nitrite are added to a solution of 1 g of 6,6-diphenyl-1-(4-toluenesulphonyl)-6,7-dihydro-1H-indazol-3-ylamine in 10 cm3 of diiodomethane, and the solution obtained is heated in the region of 80° C. for one hour. The mixture is purified directly by flash chromatography on a column of silica [eluent: cyclohexane/ethyl acetate (95/5 by volume)], and 0.6 g of 3-iodo-6,6-diphenyl-1-(4-toluenesulphonyl)-6,7-dihydro-1H-indazole is obtained in the form of a solid, the characteristics of which are as follows: