Methyl iodide → Diphenoxymethane

HRID 1243962

반응식

HRID 1243962 반응식
[O:1]([C:8]1C=CC(O)=CC=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:15][C:16](C)([O-:18])[CH3:17].[K+].CI.[CH2:23]1[CH2:27]OC[CH2:24]1>>[O:18]([CH2:8][O:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:16]1[CH:17]=[CH:27][CH:23]=[CH:24][CH:15]=1

참가 물질

5

반응물 4

HCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 132544-PhenoxyphenolHCID 23665647Potassium tert-butoxide

생성물 1

HCID 78183Diphenoxymethane

실험 절차

4-(Phenoxy)phenol (9.31 g, 50 mmol) in THF (100 mL) was treated with potassium t-butoxide (6.17 g, 55 mmol) at room temperature for 10 min. Methyl iodide (7.87 g, 55 mmol) was added by syringe. After stirring for 18 h at room temperature the reaction was quenched with saturated ammonium chloride solution and diluted with ethyl ether. The separated organic layer was washed with saturated ammonium chloride solution, dried with magnesium sulfate, filtered and concentrated to give 9.98 g of the title compound as a pale yellow oil. GS-MS (m/z, EI): 200 [M]+.

후처리

  1. customwas quenched with saturated ammonium chloride solution
  2. additiondiluted with ethyl ether
  3. washThe separated organic layer was washed with saturated ammonium chloride solution
  4. dry with materialdried with magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-191aa6473abc48819fccfa42a9fa38cc
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07119201B2

연결된 노트

불러오는 중…