Cesium carbonate → 1-(but-3-en-1-yl)pyrrolidine

HRID 1244136노트

반응식

HRID 1244136 반응식
Br[CH2:2][CH2:3][CH:4]=[CH2:5].[NH:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1.C([O-])([O-])=O.[Cs+].[Cs+]>CN(C=O)C>[CH2:2]([N:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)[CH2:3][CH:4]=[CH2:5]

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 21241Homoallyl bromideHCID 31268Pyrrolidine

생성물 1

HCID 2507071-(but-3-en-1-yl)pyrrolidine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
120 °C

실험 절차

4-Bromo-but-1-ene (81 mg, 0.6 mmol) was added dropwise to a stirred suspension of pyrrolidine (50 μL, 0.6 mmol) and Cs2CO3 (196 mg, 0.6 mmol) in 1 mL DMF. The mixture was heated to 120° C. using microwave for 20 min, then filtered and used for the next step directly without purification.

후처리

  1. customfor 20 min
  2. filtrationfiltered
  3. customused for the next step directly without purification

출처 및 근거

ORD 기록
ord-652fca441a4a47c7b72b35d2c4ab736f
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07119205B2

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