Nitromethane → 4-Hydroxy-4-nitromethyl-1-(4-pyridyl)piperidine
반응식
[N+:1]([CH3:4])([O-:3])=[O:2].[Na].[N:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH2:13]2)=[CH:8][CH:7]=1>CO>[OH:18][C:15]1([CH2:4][N+:1]([O-:3])=[O:2])[CH2:14][CH2:13][N:12]([C:9]2[CH:8]=[CH:7][N:6]=[CH:11][CH:10]=2)[CH2:17][CH2:16]1참가 물질
5
실험 절차
To a solution of nitromethane (2.31 ml) in methanol (5.4 ml) was added sodium (70 mg) at ice-cooled temperature. The resulting mixture was added dropwise to a solution of 1-(4-pyridyl)-4-piperidone (5.36 g) in methanol (10.7 ml) at ice-cooled temperature for 10 minutes, and stirred for 15 hours at room temperature. The precipitate was filtered, and washed with methanol to obtain the title compound (5.31 g).
후처리
- temperaturecooled temperature
- temperaturecooled temperature for 10 minutes
- filtrationThe precipitate was filtered
- washwashed with methanol
출처 및 근거
- ORD 기록
- ord-d9599f7173324e9ea78140f997f09029
- 출처 데이터셋
- uspto-grants-2006_10
- 특허 번호
- US07122662B2
반응 노트
불러오는 중…