N,N-Dimethylaniline → (+/-)-(1-Aminomethyl-3,3-dimethyl-cyclopentyl)-acetic acid hydrochloride

반응식

[CH3:1][C:2]1([CH3:12])[CH2:11][CH2:10][C:4]2([CH2:8][NH:7][C:6](=[O:9])[CH2:5]2)[CH2:3]1.C1(C)C=CC(S(NN=CC([Cl:27])=O)(=O)=[O:20])=CC=1.CN(C)C1C=CC=CC=1.C(N(CC)CC)C>C1(C)C=CC=CC=1.C1C=CC=CC=1.C(Cl)(Cl)Cl.C(Cl)Cl>[ClH:27].[NH2:7][CH2:8][C:4]1([CH2:5][C:6]([OH:20])=[O:9])[CH2:10][CH2:11][C:2]([CH3:12])([CH3:1])[CH2:3]1

참가 물질

실험 절차

In step four, the alcohol 4 is treated with glyoxylic acid chloride (p-toluenesulfonyl)hydrazone and N,N-dimethylaniline followed by triethylamine in a solvent such as methylene chloride, chloroform, benzene, or toluene to give the diazoacetate 5.

출처 및 근거

ORD 기록: ord-73cdc15d1da94f7c8c6c8531d5f9e082
출처 데이터셋: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07122678B2

반응 노트

불러오는 중…

참가 물질

반응물 4

HCID 949N,N-Dimethylaniline

HCID 8471Triethylamine

HCID 21923172HCID 21923172, 화합물

HCID 57296158Glyoxylyl Chloride p-toluenesulfonylhydrazone

생성물 1

HCID 69533136(+/-)-(1-Aminomethyl-3,3-dimethyl-cyclopentyl)-acetic acid hydrochloride

시약·촉매·용매 4

HCID 241Benzene용매