Sodium Hydroxide → 4-Methyl-5-naphthalen-1-yl-thiazole-2-carboxylic acid

HRID 12453

반응식

HRID 12453 반응식
C([O:3][C:4]([C:6]1[S:7][C:8]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=2)=[C:9]([CH3:11])[N:10]=1)=[O:5])C.[OH-].[Na+]>O.C1COCC1>[CH3:11][C:9]1[N:10]=[C:6]([C:4]([OH:5])=[O:3])[S:7][C:8]=1[C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 593384494-Methyl-5-naphthalen-1-yl-thiazole-2-carboxylic acid ethyl ester

생성물 1

HCID 593378204-Methyl-5-naphthalen-1-yl-thiazole-2-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4-methyl-5-naphthalen-1-yl-thiazole-2-carboxylic acid ethyl ester (30 mg, 0.10 mmol) in water (1 ml) and THF (1 ml) is added sodium hydroxide (0.2 mL, 1M, 0.20 mmol). The reaction mixture is stirred at rt for 1 hr, and then extracted with ethyl ether (30 mL). The aqueous layer is acidified to pH<7.0 by phosphate buffer and then extracted with EtOAc (2×50 mL). The combined organic layers are washed with brine, dried over MgSO4, and then concentrated. The crude product is used in the next step without further purification.

후처리

  1. extractionextracted with ethyl ether (30 mL)
  2. extractionextracted with EtOAc (2×50 mL)
  3. washThe combined organic layers are washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated
  6. customThe crude product is used in the next step without further purification

출처 및 근거

ORD 기록
ord-a99f6adcd06645219a6b3df332299ba2
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728009B1

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