Morpholine → HCID 21912455, 화합물
반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[C:9]([F:16])=[N:10][C:11]([F:15])=[N:12][C:13]=1F.C(N(CC)C(C)C)(C)C>O1CCOCC1>[Cl:7][C:8]1[C:13]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[N:12][C:11]([F:15])=[N:10][C:9]=1[F:16]참가 물질
5
실험 절차
Morpholine (0.774 mg) was added to a solution of 5-chloro-2,4,6-trifluoropyrimidine (1.5 g), N,N-diisopropylethylamine (1.15 g) in 1,4-dioxane (30 ml) and stirred at room temperature for 16 h. The mixture was partitioned between ethyl acetate and water, the organic layer dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 8% ethyl acetate in isohexane. Yield 0.88 g
후처리
- customThe mixture was partitioned between ethyl acetate and water
- dry with materialthe organic layer dried (MgSO4)
- customevaporated under reduced pressure
- customThe residue was purified by chromatography on silica eluting with 8% ethyl acetate in isohexane
출처 및 근거
- ORD 기록
- ord-5714b6dcb91a4d8594eae8c3cece52d6
- 출처 데이터셋
- uspto-grants-2006_10
- 특허 번호
- US07125881B2
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