Sodium Cyanide → 5-Chloro-4-[(4-chlorophenyl)amino]-6-morpholin-4-ylpyrimidine-2-carbonitrile

HRID 1245420노트

반응식

HRID 1245420 반응식
[C-:1]#[N:2].[Na+].[Cl:4][C:5]1[C:6]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[N:7][C:8](F)=[N:9][C:10]=1[N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CS(C)=O>[Cl:4][C:5]1[C:6]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[N:7][C:8]([C:1]#[N:2])=[N:9][C:10]=1[N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1

참가 물질

4

반응물 2

HCID 8929Sodium CyanideHCID 219124595-chloro-N-(4-chlorophenyl)-2-fluoro-6-morpholin-4-ylpyrimidin-4-amine

생성물 1

HCID 99751475-Chloro-4-[(4-chlorophenyl)amino]-6-morpholin-4-ylpyrimidine-2-carbonitrile

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Sodium cyanide (0.057 g) was added to a solution of the product from step (ii) (0.2 g) in dimethylsulphoxide (5 ml) and the mixture stirred at room temperature. After 18 h, the mixture was partitioned between ethyl acetate and water, the organics separated, washed with water, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 5% ethyl acetate in toluene. Yield 0.09 g

후처리

  1. customthe mixture was partitioned between ethyl acetate and water
  2. washthe organics separated, washed with water
  3. dry with materialdried (MgSO4)
  4. customevaporated under reduced pressure
  5. customThe residue was purified by chromatography on silica eluting with 5% ethyl acetate in toluene

출처 및 근거

ORD 기록
ord-9b1c15c5dfed432f9e2848d9e640daaa
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07125881B2

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