Dimethylformamide → 2-(2-bromophenoxy)ethanol
반응식
C(=O)([O-])[O-].[K+].[K+].[Br:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14].CN(C)C=O.Br[CH2:21][CH2:22][OH:23]>O>[Br:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][CH2:21][CH2:22][OH:23]참가 물질
6
반응 조건
- 온도
- 50 °C
실험 절차
Potassium carbonate (23.8 g) and 2-bromophenol (14.9 g) were mixed with dimethylformamide (150 ml). 2-Bromoethanol (12.9 g) was added and the mixture heated to 50° C. for 18 h. The mixture was cooled and added to water (1500 ml). The product was extracted into diethyl ether (×3) and washed twice with dilute sodium hydroxide solution. Evaporation gave 2-(2-bromophenoxy)ethanol (17.4 g).
후처리
- temperatureThe mixture was cooled
- extractionThe product was extracted into diethyl ether (×3)
- washwashed twice with dilute sodium hydroxide solution
- customEvaporation
출처 및 근거
- ORD 기록
- ord-617afdc610814f1a89167903bbd13fcc
- 출처 데이터셋
- uspto-grants-2006_10
- 특허 번호
- US07125896B2
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