Lithium Hydroxide → 1-Ethyl-2-(naphthalen-1-yl)-1H-imidazole-4-carboxylic acid

HRID 12460노트

반응식

HRID 12460 반응식
C([O:3][C:4]([C:6]1[N:7]=[C:8]([C:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=[CH:15][CH:14]=2)[N:9]([CH2:11][CH3:12])[CH:10]=1)=[O:5])C.[OH-].[Li+]>C1COCC1.O>[CH2:11]([N:9]1[CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=[C:8]1[C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)[CH3:12]

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 686285741-ethyl-2-naphthalen-1-yl-1H-imidazole-4-carboxylic acid ethyl ester

생성물 1

HCID 534224541-Ethyl-2-(naphthalen-1-yl)-1H-imidazole-4-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
50 °C

실험 절차

1-Ethyl-2-naphthalen-1-yl-1H-imidazole-4-carboxylic acid ethyl ester (2.2 g, 7.48 mmol) is dissolved in THF (20 ml), followed by the addition of aqueous lithium hydroxide solution (2.0 N, 7.5 ml, 2.0 eq.). The mixture is heated at 50° C. overnight. THF is stripped off under reduced pressure, and the residue is diluted with water (10 ml), basified to pH=4˜5. The solid precipitate is collected, washed with water and ether, dried under high vacuum to give the title compound. LCMS 267 (M+1).

후처리

  1. customThe solid precipitate is collected
  2. washwashed with water and ether
  3. customdried under high vacuum

출처 및 근거

ORD 기록
ord-e1d19fefd1aa46a38ad1627104fb90fd
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728009B1

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