Sodium Dithionite → 5,6-Diamino-3-propylpyrimidine-2,4(1H,3H)-dione

HRID 1246235노트

반응식

HRID 1246235 반응식
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4](=[O:12])[C:3]=1[N:13]=O.S(S([O-])=O)([O-])=O.[Na+].[Na+]>N>[NH2:13][C:3]1[C:4](=[O:12])[N:5]([CH2:9][CH2:10][CH3:11])[C:6](=[O:8])[NH:7][C:2]=1[NH2:1]

참가 물질

4

반응물 2

HCID 24489Sodium DithioniteHCID 144253236-Amino-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 109542025,6-Diamino-3-propylpyrimidine-2,4(1H,3H)-dione

시약·촉매·용매 1

HCID 222Ammonia용매

반응 조건

온도
5 °C

실험 절차

To a solution of 6-amino-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione (5.4 g, 27 mmol) in 12.5% aqueous ammonia (135 ml) at 70° C. was added sodium dithionite (Na2S2O4, 9.45 g, 54 mmol) in portions over 15 minutes, and the mixture was stirred for 20 minutes. The solution was concentrated under reduced pressure, cooled to 5° C., the precipitate filtered off, and washed with cold water, to provide 5,6-diamino-3-propyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (12).

후처리

  1. concentrationThe solution was concentrated under reduced pressure
  2. filtrationthe precipitate filtered off
  3. washwashed with cold water

출처 및 근거

ORD 기록
ord-9df93f57d9e3402fb16290214eb87b4f
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07125993B2

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