Methanol → HCID 21914786, 화합물

HRID 1246434노트

반응식

HRID 1246434 반응식
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([NH:8][C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])[S:6][CH:7]=1.CO>[O-2].[Mn+4].[O-2].C(Cl)(Cl)Cl>[CH:2]([C:3]1[N:4]=[C:5]([NH:8][C:9](=[O:13])[CH:10]([CH3:11])[CH3:12])[S:6][CH:7]=1)=[O:1]

참가 물질

5

반응물 2

HCID 887MethanolHCID 21914755HCID 21914755, 화합물

생성물 1

HCID 21914786HCID 21914786, 화합물수율 70.9%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

A mixture of N-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-2-methylpropanamide (520 mg), manganese (IV) oxide (2.26 g), methanol (0.5 ml) and chloroform (5 ml) was stirred at ambient temperature for 18 hours. The reaction mixture was filtered through a celite pad, and the filtrate was concentrated in vacuo. The crystalline residue was collected and washed with diisopropyl ether to give N-(4-formyl-1,3-thiazol-2-yl)-2-methylpropanamide (365 mg).

후처리

  1. filtrationThe reaction mixture was filtered through a celite pad
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe crystalline residue was collected
  4. washwashed with diisopropyl ether

출처 및 근거

ORD 기록
ord-1a3d61a319ec42eebdf602e67cfe4c37
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07125901B2

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