Methyl iodide → 1-benzyl-2-(methoxycarbonyl)-5-(methylthio)-3,4-dihydro-2H-pyrrolium iodide

HRID 1246700노트

반응식

HRID 1246700 반응식
[CH2:1]([N:8]1[C:12](=[S:13])[CH2:11][CH2:10][CH:9]1[C:14]([O:16][CH3:17])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:18][CH3:19]>>[I-:18].[CH2:1]([N+:8]1[CH:9]([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:11][C:12]=1[S:13][CH3:19])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 6328Methyl iodideHCID 14759675Methyl 1-benzyl-5-thioxo-2-pyrrolidinecarboxylate

생성물 1

HCID 865958731-benzyl-2-(methoxycarbonyl)-5-(methylthio)-3,4-dihydro-2H-pyrrolium iodide

실험 절차

Methyl 1-benzyl-5-thioxo-2-pyrrolidinecarboxylate (16.5 g, 66.2 mmol) in iodomethane (70 mL) was stirred overnight at room temperature. The mixture was concentrated under reduced pressure to provide the title compound which was used in the next step without further purification. 1H NMR (CDCl3) δ 2.24 (m, 1H), 3.04 (s, 3H), 3.16 (m, 1H), 3.25 (m, 1H), 3.63 (s, 3H), 4.29 (dd, 1H), 4.72 (d, 1H), 4.89 (dd, 1H), 5.14 (d, 1H), 7.43 (m, 3H), 7.51 (m, 2H).

후처리

  1. concentrationThe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7f98bbabb7804e23af4bd5e0ec642d2e
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129235B2

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