4-Aminophenol → 1-(4-hydroxyphenyl)-1H-pyrrole-2,5-dione

HRID 1247004

반응식

HRID 1247004 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[C:9]1(=O)[O:14][C:12](=[O:13])[CH:11]=[CH:10]1>C(O)(=O)C>[OH:8][C:5]1[CH:6]=[CH:7][C:2]([N:1]2[C:12](=[O:13])[CH:11]=[CH:10][C:9]2=[O:14])=[CH:3][CH:4]=1

참가 물질

4

반응물 2

HCID 4034-AminophenolHCID 7923Maleic Anhydride

생성물 1

HCID 817341-(4-hydroxyphenyl)-1H-pyrrole-2,5-dione수율 33%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

The suspension that consists of 5.0 g (45.8 mmol) of 4-aminophenol, 4.49 g of maleic acid anhydride and 40 ml of acetic acid is refluxed for 3 hours. It is concentrated by evaporation, residual acetic acid is removed azeotropically by repeated distillation with acetic acid, and the residue is purified by chromatography on fine silica gel. 2.83 g (15.0 mmol, 33%) of the title compound is isolated.

후처리

  1. temperatureis refluxed for 3 hours
  2. concentrationIt is concentrated by evaporation, residual acetic acid
  3. customis removed azeotropically
  4. distillationdistillation with acetic acid
  5. customthe residue is purified by chromatography on fine silica gel

출처 및 근거

ORD 기록
ord-ac0e729cf46a477db6c37896c9c519a3
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129254B2

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