Iodoethane → HCID 69290924, 화합물

HRID 1247340노트

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HRID 1247340 반응식
[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:7]1[C:12]([F:13])=[CH:11][C:10]([O:14][CH3:15])=[CH:9][C:8]=1[F:16])[OH:6])[CH3:2].[CH2:18](I)[CH3:19]>C1(C)C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:7]1[C:12]([F:13])=[CH:11][C:10]([O:14][CH3:15])=[CH:9][C:8]=1[F:16])[O:6][CH2:18][CH3:19])[CH3:2]

참가 물질

4

반응물 2

HCID 6340Iodoethane2회HCID 69290984HCID 69290984, 화합물

생성물 1

HCID 69290924HCID 69290924, 화합물수율 100.4%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a suspension of (RS)-(2,6-difluoro-4-methoxy-phenyl)-hydroxy-acetic acid ethyl ester (13.06 g) and Ag2O (24.58 g) in toluene (100 ml) was added ethyl iodide (24.81 g). The mixture was heated to reflux for 2.5 h. Ethyl iodide (24.81 g) and Ag2O (12.29 g) were added and the mixture was refluxed for a further 7 h. The solid was filtered off and the filtate was concentrated to give (RS)-(2,6-difluoro-4-methoxy-phenyl)-ethoxy-acetic acid ethyl ester (14.6 g). Light yellow oil. MS 274.1 ([M]+)

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 2.5 h
  3. temperaturethe mixture was refluxed for a further 7 h
  4. filtrationThe solid was filtered off
  5. concentrationthe filtate was concentrated

출처 및 근거

ORD 기록
ord-62330126982a4072ab1b9d27ce5ec46d
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129238B2

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