Hydroxyamine hydrochloride → 4-(Hydroxyimino-methyl)-3-phenoxy-benzonitrile

HRID 1247345노트

반응식

HRID 1247345 반응식
[CH:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O.C([O-])(=O)C.[Na+].Cl.[NH2:24][OH:25]>C(O)C>[OH:25][N:24]=[CH:1][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 219054244-Cyano-2-phenoxybenzaldehyde

생성물 1

HCID 865930434-(Hydroxyimino-methyl)-3-phenoxy-benzonitrile수율 60.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 4-formyl-3-phenoxy-benzonitrile (2.21 g) in dry ethanol (45 ml) was added sodium acetate (0.894 g) and hydroxylamine hydrochloride (0.757 g). The mixture was stirred at rt for 4.5 h. The solvent was evaporated and the product was purified by flash chromatography (cyclohexane/EtOAc 8:2=>3:7) to give 4-(hydroxyimino-methyl)-3-phenoxy-benzonitrile (1.42 g). Light yellow solid. MS 238.1 ([M]+)

후처리

  1. customThe solvent was evaporated
  2. customthe product was purified by flash chromatography (cyclohexane/EtOAc 8:2=>3:7)

출처 및 근거

ORD 기록
ord-b1c3410b43504bfd829b5abcd5e5e57f
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129238B2

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