Water → 1H-Isoindol-1-one, 4-bromo-2,3-dihydro-7-methoxy-
반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:12].[C:13]([O-])([O-])=O.[Cs+].[Cs+].CI.O>CN(C=O)C>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:13])=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:12]참가 물질
6
실험 절차
A solution of Example 106D (103 mg, 0.45 mmol) in DMF (4 mL) was treated with Cs2CO3 (162 mg, 0.5 mmol) and methyl iodide (0.03 mL, 0.48 mmol), stirred at room temperature for 3 hours, then poured into water. The resulting precipitate was filtered to give 76 mg (70%) of the desired product. MS (ESI(+)) m/e 242,244 (M+H)+.
후처리
- filtrationThe resulting precipitate was filtered
출처 및 근거
- ORD 기록
- ord-26983ef7633a4dfd8fe5b31dd29a466a
- 출처 데이터셋
- uspto-grants-2006_10
- 특허 번호
- US07129260B2
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