13-cis-Acitretin → Acitretin

HRID 1247660

반응식

HRID 1247660 반응식
[CH3:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10](/[CH3:20])=[CH:11]/[CH:12]=[CH:13]/[C:14](/[CH3:19])=[CH:15]\[C:16]([OH:18])=[O:17])=[C:6]([CH3:21])[C:5]([CH3:22])=[C:4]([O:23][CH3:24])[CH:3]=1>CC(C)=O>[CH3:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10](/[CH3:20])=[CH:11]/[CH:12]=[CH:13]/[C:14](/[CH3:19])=[CH:15]/[C:16]([OH:18])=[O:17])=[C:6]([CH3:21])[C:5]([CH3:22])=[C:4]([O:23][CH3:24])[CH:3]=1

참가 물질

3

반응물 1

HCID 643784113-cis-Acitretin

생성물 1

HCID 5284513Acitretin수율 98.3%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Crude acetretin (10 g) was added to acetone (300 ml) and stirred at 25–30° C. for 1 hour under nitrogen atmosphere. The suspension was then filtered, washed with acetone (100 ml) and dried under vacuum at 25–30° C. to obtain pure acitretin (8 g, Assay 98.3% by HPLC).

후처리

  1. filtrationThe suspension was then filtered
  2. washwashed with acetone (100 ml)
  3. customdried under vacuum at 25–30° C.

출처 및 근거

ORD 기록
ord-0a6a1dd62a144e049522c3ad6075d89a
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129365B2

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